4th Year D.Phil. Students


   Matthew Kennedy


Marta BrambillaMatt completed his Part II in 2014, and has returned to the group to work towards a D.Phil. He is now working on the syntheses of deoxyamino analogues of natural products known as the phytosphingosines using our lithium amide conjugate addition methodology. The phytosphingosine family of natural products are aliphatic aminopolyols that have well documented biological acitivities.

 

 

Trading N and O. Part 3: Synthesis of 1,2,3,4-tetrahydroisoquinolines from α-hydroxy-β-amino esters
Davies, S. G.; Fletcher, A. M.; Frost, A. B.; Kennedy, M. S.; Roberts, P. M.; Thomson, J. E. Tetrahedron 2016
72, 2139 [View Journal Page]
Asymmetric synthesis of 3-deoxy-3-aminosphingoid bases:approaches based on parallel kinetic resolution
and double asymmetric induction
Csatayová, K.; Davies, S. G.; Fletcher, A. M.; Fowler, T. R.; Kennedy, M. S.; Roberts, P. M.; Thomson, J. E.
J. Org. Chem. 2017, DOI: 10.1021/acs.joc.7b02233 [View Journal Page]
 

   David Zimmer


Alex WhiteDavid completed his Part II in 2014, and has returned to the group to work towards a D.Phil. He is working on the asymmetric synthesis of a range of azabicyclic templates. The key step in his synthesis involves the use of a chiral auxiliary to control the installation of stereocentres via use of the group's established lithium amide conjugate addition methodology.
 

 


Pyrrolizidines, indolizidines and quinolizidines via a double reductive cyclisation protocol: concise asymmetric syntheses of (+)-trachelanthamidine, (+)-tashiromine and (+)-epilupinine
Brambilla, M.; Davies, S. G.; Fletcher, A. M.; Roberts, P. M.; Thomson, J. E.; Zimmer, D. Tetrahedron 2016
72, 7417  [View Journal Page]
(−)-Pseudodistomin E: first asymmetric synthesis and absolute configuration assignment
Davies, S. G.; Fletcher, A. M.; Roberts, P. M.; Thomson, J. E.; Zimmer, D. Org. Lett. 201719, 1638
[View Journal Page]
 

 

3rd Year D.Phil. Students


   Solange Da Silva Pinto


Marta Brambilla

Solange has has previously worked with us as a summer student, working on a project concerned with the asymmetric synthesis of
(–)-cusparine. 
She has now returned to the group to study towards a D.Phil. Her project is concerned with the development of a route for the synthesis of conduramines and dihydroonduramines using our chemo- and diastereoselective, metal-free, ammonium-directed dihydroxylation methodology.
 
 
 
 
Stereoselective ammonium-directed epoxidation in the asymmetric syntheses of dihydroconduramines
(−)-A-2, (−)-B-2, (−)-C-3 and (+)-F-3
Da Silva Pinto, S.; Davies, S. G.; Fletcher, A. M.; Roberts, P. M.; Thomson, J. E. Synthesis 2017, in press 


 

2nd Year D.Phil. Students

   

   Katie Holder



Katie completed her Part II in 2016, and has returned to the group to work towards a D.Phil. She is now working on the syntheses of deoxynojirimycins using our lithium amide conjugate addition and 'Trading N and O' methodologies.

 

 

 

 

   Sean Linsdall


 

Sean completed his Masters degree at Imperial College London working for Prof. Alan Spivey. He joined our group on October 2016 and is working on the the asymmetric synthesis of the loline alkaloids using a combination of our lithium amide conjugate addition and 'Trading N
and O' protocols as the key steps.

 

 

 

 

 

1st Year D.Phil. Students


   Cameron Taylor 


Marta Brambilla

Cameron completed his MChem at Oxford in 2017, and is now studying for a DPhil in the group. His project is aimed towards the synthesis of a selective cytotoxic agent for colon cancer cells using the group's lithium amide conjugate addition as a key stereo-defining step.











 


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