Matt completed his Part II in 2014, and has returned to the group to work towards a D.Phil. He is now working on the syntheses of deoxyamino analogues of natural products known as the phytosphingosines using our lithium amide conjugate addition methodology. The phytosphingosine family of natural products are aliphatic aminopolyols that have well documented biological acitivities.
Trading N and O. Part 3: Synthesis of 1,2,3,4-tetrahydroisoquinolines from α-hydroxy-β-amino esters
Davies, S. G.; Fletcher, A. M.; Frost, A. B.; Kennedy, M. S.; Roberts, P. M.; Thomson, J. E. Tetrahedron 2016,
72, 2139 [View Journal Page]
David completed his Part II in 2014, and has returned to the group to work towards a D.Phil. He is working on the asymmetric synthesis of a range of azabicyclic templates. The key step in his synthesis involves the use of a chiral auxiliary to control the installation of stereocentres via use of the group's established lithium amide conjugate addition methodology.
Pyrrolizidines, indolizidines and quinolizidines via a double reductive cyclisation protocol: concise asymmetric syntheses of (+)-trachelanthamidine, (+)-tashiromine and (+)-epilupinine
Brambilla, M.; Davies, S. G.; Fletcher, A. M.; Roberts, P. M.; Thomson, J. E.; Zimmer, D. Tetrahedron 2016,
72, 7417 [View Journal Page]