Harnessing the potential of stem cells is one of the next major challenges in medicine and healthcare. The control of a stem cells fate with the use of small molecules to control the destiny of stem cells is an emerging discipline which offers unprecedented advantages over other techniques in terms of speed, cost, reproducibility and the ability to influence stem cell fate reversibly. We have recently developed a set of small molecules capable of embryonic stem cell proliferation in the absence of protein-based growth factors.
Current work within the group is investigating the use of small molecules on the directed differentiation pathways of pluripotent eSCs down specific lineages towards specialised tissue types such as neurons and cardiomyocytes. We have strong collaborations with the Oxford Stem Cell Institute and the British Heart Foundation Centre of Research Excellence, working with Angela Russell (Departments of Chemistry and Pharmacology), Paul Riley (Department of Physiology, Anatomy and Genetics), Robert MacLaren (Nuffield Laboratory of Ophthalmology), William James (Sir William Dunn School of Pathology), Roger Patient (Weatherall Institute of Molecular Medicine), Mathew Wood (Department of Physiology, Anatomy and Genetics), Suzanne Watt (Nuffield Department of Clinical Laboratory Sciences), and Francis Szele (Department of Physiology, Anatomy and Genetics). We are also currently collaborating on a recently awarded €55.6m EU FP7 Innovative Medicines Initiative Grant: StemBANCC, Stem Cells for Drug Discovery, led by Zameel Cader (Department of Clinical Neurology, Oxford).
This work has been funded by the BBSRC, EPSRC and the British Heart Foundation.
- Stemistry: the control of stem cells in situ using chemistry
Davies, S. G.; Kennewell, P. D.; Russell, A. J.; Seden, P. T.; Westwood, R.; Wynne, G. M. J. Med. Chem. 2015, 58, 2863 [View Journal Page]
- Hedgehog and Bmp Polarize Haematopoietic Stem Cell Emergence in the Zebrafish Dorsal Aorta Wilkinson R. N.; Pouget C.; Gering M.; Russell A. J.; Davies S. G.; Kimelman D.; Patient R. Developmental Cell, 2009, 16, 909 [View Jounal Page]
- Abrogation of E-cadherin Mediated Cell-cell Contact in Mouse Embryonic Stem Cells Results in Reversible LIF-independent Self Renewal Soncin F.; Mohamet L.; Eckardt D.; Ritson S.; Eastham A. M.; Bobola N.; Russell A. J. Davies S. G.; Kelmer R.; Marry C. L.; Ward C. M. Stem Cells, 2009, 27, 2069
[View Journal Page]